Technologies Available

Technologies Available

Manufacturing, Engineering, Energy & Water Technologies

 

Sensors

ColiSense  - A Rapid, Field Portable Sensor for E. Coli Detection in Water
ColiSense is a field portable sensor system for the rapid on-site detection of E. Coli bacteria in recreational waters. The system is based on a sensitive, field portable fluorimeter, with incubating capability and triplicate sample chambers to analyse fluorescent based enzyme assays. Traditionally, samples from recreational waters need to be sent away to analytical laboratories for analysis, which can cause a significant delay in the identification of bacterial levels above the acceptable bathing water standards. The ColiSense system provides a result in 75 minutes, enabling same day action in the case of a pollution event.

MobiMate - Smartphone-based Personal Health Management
MobiMate is a personal health monitoring tool that exploits smartphone technology to enable the user to monitor a wide range of chronic illnesses. The system exploits an off-the-shelf smartphone, a custom-designed sensor module and a disposable sensor chip – single-use; pinprick blood sample. The system is suitable for use with sensitive, fluorescence-based bioassays. Initial studies have focussed on C-reactive protein monitoring for rheumatoid arthritis patients. The system is customisable for real-time generation of biochemical data and results may be provided directly to the user or communicated remotely to a clinician.

Light-responsive, Low Power Valves for Microfluidics & Lab-on-a Chip
Light-responsive, reversible valves have been developed using hydrogel materials. The valves open and close via light actuation, enabling a non-contact, low power, valve solution for microfluidic based sensor systems such as lab-on-a-chip. The solution provides a simple, low power and compact solution for fluid control within a microfluidic channel, with simple LED illumination. The use of millimetre dimension surface mounted LEDs in combination with similarly sized gel valves creates the opportunity to create arrays of valves to perform more complex functions, while remaining compact and portable. In addition to open and close functionality, the application of pulsed light results in oscillation of the hydrogel valves to provide a method of tuneable flow control.

 

Plasma

Non-Invasive Plasma Diagnostic Sensor based on Radio Emission Spectroscopy
Plasma based processes are widely used in a variety of industrial applications such as low pressure semiconductor manufacture and atmospheric pressure plasma coating and surface treatments. Industrial plasma users are continually seeking improved process diagnostics and fault detection. This technology is a non-invasive plasma sensor, which is non-perturbing to the plasma and requires minimal retro-fitting to existing equipment. The sensor is based on Radio Emission Spectroscopy (RES), a magnetic loop antenna is inductively coupled to nearby plasma current emitted in the radio near field. The sensor can be placed outside of the plasma chamber in close proximity e.g. next to a view-port, enabling localised signal detection. The sensor can be used for process endpoint detection, process excursion monitoring, chamber matching and detection of chamber contamination, pump failure and leak detection.

 

Materials Processing

Laser-textured Interference-fit Fasteners with Highly Controlled Bond Strength
Interference-fit fasteners are a popular method of joining, due to the relative ease of manufacture and simplicity in design. These fasteners are widely used in a range of industrial sectors including aerospace, automotive, biomedical and ICT hardware. Conventionally, interference joints are made via a press or shrink fit, however, these methods can lead to issues with excessive plastic deformation or defect initiation in the joint region, resulting in lower lifetimes. This technology is a novel, rapid laser micro-profiling technique for producing interference fit fasteners. In this technique, a high powered laser is used to alter the surface texture of a metal pin, to produce an interference-fit fastener that will have a more highly defined bond strength and result in more secure interference joints. Control of the laser parameters allows exacting control of the surface texture, giving a high degree of control over the strength of the fastening and resulting in a longer life time of the joint.


Energy

Compact, Light Weight, Fuel Cell Power Module
Fuel cells are an attractive source of power for portable electronic devices, automotive and utility vehicles and power back-up. They convert a fuel, such as hydrogen, into electricity in a clean and efficient manner. This technology is a novel design of a proton exchange membrane (PEM) fuel cell, which overcomes several limitations of existing fuel cells. The design employs a metal foam as a common fluid flow manifold between adjacent fuel cells, which avoids the use of expensive and heavy metal end plates, which are bulky, heavy and expensive to manufacture due to the machining requirements. The technology can be scaled for multiple applications. The group is currently investigating portable power for drone applications, where the DCU technology can provide significantly longer life (flight time) compared with comparable sized conventional battery solutions.

 

Water

ColiSense  - A Rapid, Field Portable Sensor for E. Coli Detection in Water
ColiSense is a field portable sensor system for the rapid on-site detection of E. Coli bacteria in recreational waters. The system is based on a sensitive, field portable fluorimeter, with incubating capability and triplicate sample chambers to analyse fluorescent based enzyme assays. Traditionally, samples from recreational waters need to be sent away to analytical laboratories for analysis, which can cause a significant delay in the identification of bacterial levels above the acceptable bathing water standards. The ColiSense system provides a result in 75 minutes, enabling same day action in the case of a pollution event.

 

 

 

 

Life Science Technologies

 

Biotech/ Pharma R&D

Novel compound for the treatment of inflammatory disease                                                                        
Researchers at DCU and UCD have identified a compound purified from a marine species that exerts potent anti-inflammatory activity. The mechanism of action has been elucidated and the team have shown that the intracellular target for this compound is an adaptor protein involved in a key pathway in the immune system, the toll-like receptor (TLR) pathway. The specific target that has been identified is exclusively associated with TLR2 and TLR4 which play a major role in inflammatory disease.  A “clinical ready” formulation of the lead compound suitable for topical application has been developed and a number of pre-clinical toxicology studies have been performed. The compound has shown promising results in a murine model of atopic dermatitis.
For more information , please contact Emma O’Neill – emma.oneill@invent.dcu.ie Tel: +353 1 7007741

Memsense  - Advanced Lipid Bilayer Membrane Model Platform for Drug Discovery
MemSense is an advanced lipid bilayer membrane model platform suitable for pre-formulation studies of new molecules and drug delivery vehicles in drug discovery in the pharmaceutical & cosmetics industry. MemSense effectively mimics the cell membrane in terms of its composition and fluidity. In addition, it offers the possibility of inclusion of transmembrane proteins which are both mobile and retain their active conformation.
For more information , please contact Emma O’Neill – emma.oneill@invent.dcu.ie Tel: +353 1 7007741

Improved productivity in CHO Cell Lines for Biopharmaceutical Production
The majority of biopharmaceuticals are manufactured using Chinese Hamster Ovary (CHO) cells which are grown in large bioreactors. Although the efficiency of CHO-based processes has improved in the last two decades, they are considerably less productive than bacterial or yeast systems. DCU has developed technology that can offer significant enhancements in process efficiencies. 
For more information , please contact Emma O’Neill – emma.oneill@invent.dcu.ie Tel: +353 1 7007741
 


Medical Devices

Enduragel - a Novel Therapeutic Filling Material for Treatment of Cerebral Aneurysms
The Biomaterials Research Group in DCU have created a novel, innovative, patented technology, Enduragel, which is an injectable hydrogel for the treatment of brain aneurysms. A brain aneurysm is a localised dilation (bulge) of a blood vessel surrounding the brain. If untreated, the aneurysm can rupture causing bleeding into the brain. This often results in severe disability or death. It is estimated that approximately 700,000 people globally experience an aneurysm rupture each year.  The hydrogel can be injected through very fine tubes (catheters) – less than 1mm in diameter – and into the aneurysm. It then gels, forming a barrier to blood ingress and further aneurysm expansion. The technology may also be used to treat other vascular problems such as Arteriovenous Malformations (AVMs) and dural fistulas, among others.
For more information , please contact Emma O’Neill – emma.oneill@invent.dcu.ie Tel: +353 1 7007741

 

Diagnostics

Sepsis Detection Platform                                                                                                                                        
SepTec  is a  novel centrifugal microfluidic disc platform technology for the rapid detection of pathogens in whole blood. Based on electrochemical detection, definitive identification of pathogens in a 2ml volume of whole blood is achieved with a rapid, sample to answer time of 15 minutes. The SepTec device is currently undergoing validation through pre-clinical studies in collaboration with The Coombe Women & Children’s Hospital, St. James’s Hospital and Beaumont Hospital.
For more information , please contact Emma O’Neill – emma.oneill@invent.dcu.ie Tel: +353 1 7007741

Novel Panel of Breast Cancer Biomarkers
The Proteomics group at the NICB have discovered a novel panel of biomarkers that will significantly improve the method of measuring the response of an individual with breast cancer to various therapies and of diagnosing the recurrence of breast cancer. A European patent application is pending and a clinical study is underway at St. Vincent’s Hospital Dublin.
For more information , please contact Emma O’Neill – emma.oneill@invent.dcu.ie Tel: +353 1 7007741

High Performance Diagnostic Antibodies
AbYBiotech has developed from the Applied Biochemistry Group at Dublin City University and has over 35 years of experience of antibody production and immunoassay design. The focus is on the development of high performance antibodies, produced mainly by recombinant approaches. This has allowed the tailoring of antibodies for specific applications and detection platforms ensuring correct orientation, ultra-low affinities and high sensitivity, excellent specificities, and stability. AbYBiotech has a portfolio of antibodies and antibody derivatives and very significant expertise in novel immunoassay development. For more information on AbYBiotech and for the catalogue of antibodies see http://abybiotech.com/antibodies/catalogue/